Dr Frank Boulton
WS
P13 - Is it correct to understand from this, that the priority for him was that the powder dissolved more quickly?
P15 - To what degree were they under-emphasised? Can he be more specific?
P21 - He says "Preston had shown that blood tests of liver enzyme activity were consistent with the biopsy findings" - Is it right then to understand that was a somewhat accurate marker?
P23 - Does he recall if Immuno was a red or blue box? Was he aware of the red/blue box difference? What about at a later stage?
Repeat this re P47 - he states again European donors.
Repeat at P94
P93 - What about the differing level of risks from different products?
P95 - Why not on option? (When studies form pre concentrates show it was consistently more than fine for both)
"The present availability of cryoprecipitate makes the temporary correction of the hemostatic defect in classical hemophilia possible, and allows full investigation and surgical treatment of intracranial or other haemorrhage, as in a normal person. A timid approach to surgery in the hemophiliac patient is no longer justified." Link Removed
This study is important because it describes successful prophylactic cryo home treatment and specifically states it is for severe haemophiliacs. Link Removed
"He soon learnt to administer his own intravenous injections and was able to continue this regimen, storing a week's supply of cryoprecipitate at home in a deep freeze" Link Removed
P153 - This is also true for Hep C in the 1970s isn’t it?
P155 - First sentence. Given what he says, and if one was to assume that synthetic FVIII was never invented. Would he accept that it would only be a matter of time, however long that might be, until a serious pathogen enters the blood supply and untreated pooled product leads to the wide scale catastrophe that unfolded?
P155 - His final para. Was this ever set out, in those terms, to patients?
Should it have been?
P156 - Cryo “complex for staff” he says, why doesn’t this accord?
"The manufacturing procedure is quite simple, requiring no special skill or training" Link Removed
"simple and inexpensive" - "can be done in any blood bank" - "assures the hemophiliac of an ample supply" https://www.newspapers.com/clip/81154313/
"Cryoprecipitate is also relatively simple and inexpensive to prepare" Link Removed
"provides a simple means of preparation of potent antihaemophilic globulin concentrates, suitable for introduction as a routine blood-banking procedure" Link Removed
"cryoprecipitate can be prepared easily and economically by hospital blood banks" Link Removed
P159 - What were the practical problems?
P287 - Did Craske given him any sense of how many more there might be? 1 more, 2 more, or an unknown number?
P387:
“Low but not absent risk of sexual transmission” - Would he maintain that is true and equal for all forms of possible sexual transmission? - Given what was known, even in the 1970s, about gay men.
Lost ref but in his WS he describes the introduction of Cryo as a “sea change”. Would he agree that the introduction of Cryo brought significantly improved life expectancy for haemophiliacs?
